Focused ultrasound to open the blood brain barrier, tested with standard immune therapy for lung cancer that spread to the brain
Official title: Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study is testing whether focused ultrasound can safely open the blood brain barrier in people getting standard immune therapy for lung cancer that spread to the brain.
Read our full plain-language summary
What the trial team says
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients who are undergoing planned FDA approved, on-label systemic therapy utilizing immune checkpoint inhibitors.
Key facts
- Registry number
- NCT05317858
- Stage of testing
- Phase 3
- Conditions studied
- Brain Tumor, Non Small Cell Lung Cancer
Where it is running
This trial lists 14 sites.
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Arizona
- St. Joseph's Hospital and Medical Center (Phoenix)
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California
- Hoag Memorial Hospital Presbyterian (Newport Beach)
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Florida
- Broward Health (Fort Lauderdale)
- Miami Cancer Institute at Baptist Health (Miami)
- Moffitt Cancer Center (Tampa)
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Maryland
- University of Maryland (Baltimore)
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North Carolina
- Atrium Health Wake Forest Baptist (Winston-Salem)
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Ontario
- Sunnybrook Research Institute (Toronto)
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Oregon
- Oregon Health & Science University (Portland)
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Rhode Island
- Rhode Island Hospital (Providence)
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Seoul
- Samsung Medical Center (Seoul)
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South Korea
- Seoul National University Hospital (Seoul)
- Severance Hospital, Yonsei University Health System (Soeul)
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Virginia
- Johnston Willis Hospital (Richmond)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.