Focused ultrasound to open the blood brain barrier, tested with standard immune therapy for lung cancer that spread to the brain
Original title: Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large late stage trial in people, but it is still a test and not approved care.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether focused ultrasound can safely open the blood brain barrier in people getting standard immune therapy for lung cancer that spread to the brain.
Who this trial is for. This trial is for people with non-small cell lung cancer that has spread to the brain, who are already set to get an FDA approved immune checkpoint inhibitor as their standard therapy. It tests a device called Exablate Model 4000 Type 2.0/2.1, which uses focused ultrasound aimed at the brain to open the blood brain barrier.
Where it stands. There are no results here. The trial is measuring how safe this approach is and how well it works when added to standard immune therapy. The answer is not in yet. The source does not report any outcome.
What this means, and what it doesn't
What it could mean: For now, this is a study, not care your own doctor can give you. If you have lung cancer that spread to the brain and you are heading into immune therapy, you could ask your care team whether a trial like this is worth looking into for you.
What it doesn't mean: This does not mean the treatment works. A trial is a test, and the point is to find out. Joining a trial is not a guarantee that it will help you, and some people get no benefit. It is not a cure, and no one can promise you a spot.
Source: ClinicalTrials.gov, July 22, 2026 · Read the original
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