Testing a targeted radiation drug with lomustine for glioblastoma that has come back
Official title: Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This trial is testing whether adding a targeted radiation drug to lomustine: A chemotherapy you take as a capsule. You take it now and then, not every day. It lowers your blood counts weeks after a dose. That is why the doses are spaced out. See the glossary helps adults whose glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary has come back.
Read our full plain-language summary
What the trial team says
This global clinical trial which evaluates the efficacy and safety of TLX101-Tx, an investigational radiopharmaceutical therapy, in combination with lomustine versus lomustine alone in adult patients with first recurrence of glioblastoma. TLX101-Tx delivers targeted radiation to glioblastoma cells. The trial is conducted in two parts: Part 1 assesses safety and radiation dosing; Part 2 is a randomized comparison of the combination therapy against standard care.
Key facts
- Registry number
- NCT07100730
- Stage of testing
- Phase 3
- Conditions studied
- Neoplastic Disease, Glioblastoma, Glioblastoma (GBM), Glioblastoma Multiform, Glioblastoma Multiforme, Adult, Glioblastoma Multiforme (GBM) WHO Grade IV
Where it is running
This trial lists 9 sites.
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Australia
- Royal Adelaide Hospital (Adelaide)
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Austria
- Johannes Kepler University (Linz)
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Belgium
- UZ Leuven (Leuven)
- Chu of Liège (Liège)
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Netherlands
- The Netherlands Cancer Institute (NKI) (Amsterdam)
- UMC Utrecht (Utrecht)
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Queensland
- Gold Coast University Hospital (Gold Coast)
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Victoria
- Austin Health (Melbourne)
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Western Australia
- Sir Charles Gairdner Hospital (Perth)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.