Adding the drug triapine to radiation for glioblastoma or astrocytoma that has come back
Official title: Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study tests giving a drug called triapine along with radiation for a brain tumor that has come back.
Read our full plain-language summary
What the trial team says
This phase I trial tests the safety, side effects, and best dose of triapine in combination with radiation therapy in treating patients with glioblastoma or astrocytoma that has come back after a period of improvement (recurrent). Triapine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Giving triapine in combination with radiation therapy may be safe, tolerable, and/or effective in treating patients with recurrent glioblastoma or astrocytoma.
Key facts
- Registry number
- NCT06860594
- Stage of testing
- Phase 1
- Conditions studied
- Astrocytoma, IDH-Mutant, Grade 2, Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Adult Diffuse Midline Glioma, H3 K27-Mutant, Recurrent Astrocytoma, IDH-Mutant, Recurrent Astrocytoma, IDH-Mutant, Grade 3, Recurrent Astrocytoma, IDH-Mutant, Grade 4, Recurrent Glioblastoma, IDH-Wildtype
Where it is running
This trial lists 43 sites.
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California
- City of Hope Comprehensive Cancer Center (Duarte)
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care (Irvine)
- UC San Diego Moores Cancer Center (La Jolla)
- UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange)
- University of California Davis Comprehensive Cancer Center (Sacramento)
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Connecticut
- Yale University (New Haven)
- Smilow Cancer Hospital Care Center-Trumbull (Trumbull)
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District of Columbia
- MedStar Georgetown University Hospital (Washington D.C.)
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Florida
- UM Sylvester Comprehensive Cancer Center at Coral Gables (Coral Gables)
- UM Sylvester Comprehensive Cancer Center at Coral Springs (Coral Springs)
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach (Deerfield Beach)
- UM Sylvester Comprehensive Cancer Center at Doral (Doral)
- UM Sylvester Comprehensive Cancer Center at Hollywood (Hollywood)
- University of Miami Miller School of Medicine-Sylvester Cancer Center (Miami)
- UM Sylvester Comprehensive Cancer Center at Kendall (Miami)
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia (North Miami)
- UM Sylvester Comprehensive Cancer Center at Plantation (Plantation)
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Georgia
- Emory University Hospital/Winship Cancer Institute (Atlanta)
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Illinois
- Northwestern University (Chicago)
- University of Chicago Comprehensive Cancer Center (Chicago)
- Memorial Hospital East (Shiloh)
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Kansas
- University of Kansas Clinical Research Center (Fairway)
- University of Kansas Cancer Center (Kansas City)
- University of Kansas Hospital-Westwood Cancer Center (Westwood)
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Kentucky
- University of Kentucky/Markey Cancer Center (Lexington)
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Missouri
- Siteman Cancer Center at Saint Peters Hospital (City of Saint Peters)
- Siteman Cancer Center at West County Hospital (Creve Coeur)
- Washington University School of Medicine (St Louis)
- Siteman Cancer Center-South County (St Louis)
- Siteman Cancer Center at Christian Hospital (St Louis)
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New York
- NYU Langone Hospital - Long Island (Mineola)
- Laura and Isaac Perlmutter Cancer Center at NYU Langone (New York)
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center (New York)
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North Carolina
- Carolinas Medical Center/Levine Cancer Institute (Charlotte)
- Wake Forest University Health Sciences (Winston-Salem)
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Ohio
- Ohio State University Comprehensive Cancer Center (Columbus)
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Oklahoma
- University of Oklahoma Health Sciences Center (Oklahoma City)
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Pennsylvania
- UPMC Hillman Cancer Center (Pittsburgh)
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Tennessee
- Vanderbilt University/Ingram Cancer Center (Nashville)
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Utah
- Huntsman Cancer Institute/University of Utah (Salt Lake City)
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Virginia
- VCU Massey Comprehensive Cancer Center (Richmond)
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Wisconsin
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center (Madison)
- University of Wisconsin Carbone Cancer Center - University Hospital (Madison)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.