Testing three drugs together for lung cancer that spread to the brain
Official title: A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study tests three cancer drugs given together after lung cancer spreads to the brain.
Read our full plain-language summary
What the trial team says
This is a Phase II, single-arm, multicenter trial for patients with metastatic non-small cell lung cancer who have brain metastases and no known actionable mutations. Eligible patients will receive a combination of Datopotamab-deruxtecan, Carboplatin, and Pembrolizumab every three weeks for four cycles, followed by maintenance therapy with Datopotamab-deruxtecan and Pembrolizumab until disease progression or intolerable toxicity. Patients with intracranial progression but no systemic progression may receive stereotactic radiosurgery and continue treatment based on the investigator's decision.
Key facts
- Registry number
- NCT06822543
- Stage of testing
- Phase 2
- Conditions studied
- Lung Cancer, Non Small Cell Lung Cancer, Brain Metastases
Where it is running
This trial lists 13 sites.
-
Ceará
- CRIO - Centro Regional Integrado de Oncologia (Fortaleza)
-
Estado de Bahia
- Santa Casa de Misericórdia da Bahia - Hospital Santa Izabel (Oncoclínicas) (Salvador)
-
Minas Gerais
- Oncocentro de Minas Gerais (Oncoclínicas) (Belo Horizonte)
-
Pernambuco
- IMIP - Instituto de Medicina Integral Professor Fernando Figueira (Recife)
-
Rio de Janeiro
- CTTB - Centro de Tratamento de Tumores Botafogo (Oncoclínicas) (Rio de Janeiro)
-
Rio Grande do Norte
- Liga Norte Riograndense Contra o Câncer (Natal)
-
Rio Grande do Sul
- ISCMPA - Santa Casa de Porto Alegre (Porto Alegre)
- CPO - Centro de Pesquisa em Oncologia do Hospital São Lucas da PUCRS (Porto Alegre)
-
Santa Catarina
- Catarina Pesquisa Clínica - Clínica de Neoplasias Litoral (Itajaí)
-
São Paulo
- Hospital de Amor de Barretos (Barretos)
- FUNFARME - Hospital de Base de São José do Rio Preto (São José do Rio Preto)
- A.C. Camargo Cancer Center (São Paulo)
- CPO - Centro Paulista de Oncologia (Oncoclínicas) (São Paulo)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.