Memory and attention in children who had brain radiation
Official title: Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study looks at how brain radiation affects memory in children.
Read our full plain-language summary
What the trial team says
This is a prospective, open-label, multicentric study designed to correlate the dose delivered to the hippocampus with declarative memory deficits 2 years after radiotherapy treatment in a paediatric population who had received brain irradiation between the ages of 4 and 12 for a brain tumour. In order to meet this objective, several neuropsychological assessments consisting of parental questionnaires and cognitive tests will be carried out during the course of the study, at the following two stages: * A 1st assessment at patient inclusion, i.e. 2 years after the end of radiotherapy treatment, * And a second assessment 2 years after patient inclusion, i.e. 4 years after the end of radiotherapy treatment. A retrospective assessment of the patient's neurocognitive level 1 year before the diagnosis of the disease will also be carried out at inclusion, with the parents completing a questionnaire specifically designed for the trial. In addition, patients who have received their radiotherapy treatment at the IUCT-O will be offered participation in the ancillary imaging study. If the parents and the patient agree, multimodal MRI scans specific to the study (without injection of contrast) will be performed at inclusion and 2 years after inclusion. Imaging and radiotherapy data will be collected in parallel using the PediaRT software used in current practice (collection of radiotherapy dosimetric data as well as standard MRI examinations pre-operatively, post-operatively, and at the 2-year and 4-year follow-up). 130 patients will be included in this study.
Key facts
- Registry number
- NCT06599879
- Stage of testing
- Not applicable
- Conditions studied
- Brain Tumor, Pediatric
Where it is running
This trial lists 14 sites.
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France
- CHU Angers (Angers)
- CHU de Bordeaux (Bordeaux)
- Centre François Baclesse (Caen)
- Centre Oscar Lambret (Lille)
- Centre Léon Bérard (Lyon)
- APHM - Hôpital la Timone (Marseille)
- Institut du Cancer de Montpellier (Montpellier)
- Institut Curie (Paris)
- Centre Eugène Marquis (Rennes)
- Institut de Cancérologie de l'Ouest (Saint-Herblain)
- Centre Paul Strauss (Strasbourg)
- IUCT-O (Toulouse)
- and 2 more in France
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.