Comparing two radiation schedules for cancer that has spread to the brain
Official title: Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This trial compares focused radiation given in 3 treatments to the same kind given in one treatment.
Read our full plain-language summary
What the trial team says
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.
Key facts
- Registry number
- NCT06500455
- Stage of testing
- Phase 3
- Conditions studied
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
Where it is running
This trial lists 270 sites.
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Arizona
- Banner University Medical Center - Tucson (Tucson)
- University of Arizona Cancer Center-North Campus (Tucson)
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Arkansas
- Mercy Hospital Fort Smith (Fort Smith)
- University of Arkansas for Medical Sciences (Little Rock)
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California
- Kaiser Permanente-Anaheim (Anaheim)
- Kaiser Permanente-Bellflower (Bellflower)
- City of Hope Corona (Corona)
- City of Hope Comprehensive Cancer Center (Duarte)
- UC San Diego Health System - Encinitas (Encinitas)
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care (Irvine)
- City of Hope at Irvine Lennar (Irvine)
- UC San Diego Moores Cancer Center (La Jolla)
- City of Hope Antelope Valley (Lancaster)
- Kaiser Permanente Los Angeles Medical Center (Los Angeles)
- Cedars-Sinai Medical Center (Los Angeles)
- Providence Queen of The Valley (Napa)
- and 9 more in California
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Co Dublin
- Beacon Hospital (Dublin)
- Saint Lukes Hospital (Dublin)
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Co Galway
- University College Hospital Galway (Galway)
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Colorado
- UCHealth University of Colorado Hospital (Aurora)
- UCHealth Memorial Hospital Central (Colorado Springs)
- Memorial Hospital North (Colorado Springs)
- Poudre Valley Hospital (Fort Collins)
- Cancer Care and Hematology-Fort Collins (Fort Collins)
- UCHealth Greeley Hospital (Greeley)
- Medical Center of the Rockies (Loveland)
-
Connecticut
- Hartford Hospital (Hartford)
- The Hospital of Central Connecticut (New Britain)
-
Florida
- UM Sylvester Comprehensive Cancer Center at Aventura (Aventura)
- Boca Raton Regional Hospital (Boca Raton)
- UM Sylvester Comprehensive Cancer Center at Coral Gables (Coral Gables)
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach (Deerfield Beach)
- UM Sylvester Comprehensive Cancer Center at Doral (Doral)
- University of Miami Miller School of Medicine-Sylvester Cancer Center (Miami)
- Miami Cancer Institute (Miami)
- UM Sylvester Comprehensive Cancer Center at Kendall (Miami)
- UM Sylvester Comprehensive Cancer Center at Plantation (Plantation)
- Moffitt Cancer Center-International Plaza (Tampa)
- Moffitt Cancer Center - McKinley Campus (Tampa)
- Moffitt Cancer Center (Tampa)
- and 1 more in Florida
-
Georgia
- Emory University Hospital Midtown (Atlanta)
- Piedmont Hospital (Atlanta)
- Emory University Hospital/Winship Cancer Institute (Atlanta)
- Emory Saint Joseph's Hospital (Atlanta)
- WellStar Cobb Hospital (Austell)
- Wellstar Kennestone Hospital (Marietta)
-
Hawaii
- Hawaii Cancer Care Inc - Waterfront Plaza (Honolulu)
- Queen's Cancer Cenrer - POB I (Honolulu)
- Queen's Medical Center (Honolulu)
- University of Hawaii Cancer Center (Honolulu)
- Queen's Cancer Center - Kuakini (Honolulu)
- Kapiolani Medical Center for Women and Children (Honolulu)
- Castle Medical Center (Kailua)
- Wilcox Memorial Hospital and Kauai Medical Clinic (Lihue)
- Hawaii Cancer Care - Westridge (‘Aiea)
- The Queen's Medical Center - West Oahu (‘Ewa Beach)
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Hong Kong
- Pamela Youde Nethersole Eastern Hospital (Chai Wan)
-
Illinois
- Centralia Oncology Clinic (Centralia)
- Northwestern University (Chicago)
- Rush MD Anderson Cancer Center (Chicago)
- University of Chicago Comprehensive Cancer Center (Chicago)
- Carle at The Riverfront (Danville)
- Cancer Care Specialists of Illinois - Decatur (Decatur)
- Decatur Memorial Hospital (Decatur)
- Carle Physician Group-Effingham (Effingham)
- Crossroads Cancer Center (Effingham)
- Elmhurst Memorial Hospital (Elmhurst)
- Carle Physician Group-Mattoon/Charleston (Mattoon)
- Loyola University Medical Center (Maywood)
- and 12 more in Illinois
-
Indiana
- Northwest Cancer Center - Crown Point (Crown Point)
- UChicago Medicine Northwest Indiana (Crown Point)
- Northwest Oncology LLC (Dyer)
- Goshen Center for Cancer Care (Goshen)
- Northwest Cancer Center - Hobart (Hobart)
- Saint Mary Medical Center (Hobart)
- The Community Hospital (Munster)
- Women's Diagnostic Center - Munster (Munster)
- Northwest Cancer Center - Valparaiso (Valparaiso)
-
Iowa
- Mary Greeley Medical Center (Ames)
- McFarland Clinic - Ames (Ames)
- University of Iowa/Holden Comprehensive Cancer Center (Iowa City)
-
Ireland
- Cork Radiation Oncology Associates Limited (Cork)
- Cork University Hospital (Cork)
-
Kansas
- University of Kansas Cancer Center (Kansas City)
- The University of Kansas Cancer Center - Olathe (Olathe)
- University of Kansas Cancer Center-Overland Park (Overland Park)
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Kentucky
- Baptist Health Hardin (Elizabethtown)
- University of Kentucky/Markey Cancer Center (Lexington)
- The James Graham Brown Cancer Center at University of Louisville (Louisville)
- Norton Brownsboro Hospital and Medical Campus (Louisville)
- UofL Health Medical Center Northeast (Louisville)
- Owensboro Health Mitchell Memorial Cancer Center (Owensboro)
-
Maine
- MaineHealth Maine Medical Center - Portland (Portland)
- MaineHealth Cancer Care Center of York County (Sanford)
- MaineHealth Maine Medical Center- Scarborough (Scarborough)
-
Maryland
- Maryland Proton Treatment Center (Baltimore)
- University of Maryland/Greenebaum Cancer Center (Baltimore)
- Sinai Hospital of Baltimore (Baltimore)
- UM Upper Chesapeake Medical Center (Bel Air)
- Central Maryland Radiation Oncology in Howard County (Columbia)
- University of Maryland Shore Medical Center at Easton (Easton)
- UM Baltimore Washington Medical Center/Tate Cancer Center (Glen Burnie)
- UM Capital Region Medical Center (Largo)
- William E Kahlert Regional Cancer Center/Sinai Hospital (Westminster)
-
Michigan
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor (Ann Arbor)
- University of Michigan Rogel Cancer Center (Ann Arbor)
- Trinity Health IHA Medical Group Hematology Oncology - Brighton (Brighton)
- Henry Ford Cancer Institute-Downriver (Brownstown)
- Henry Ford Macomb Hospital-Clinton Township (Clinton Township)
- Henry Ford Hospital (Detroit)
- Trinity Health Saint Mary Mercy Livonia Hospital (Livonia)
- Henry Ford Health Providence Novi Hospital (Novi)
- MyMichigan Medical Center Saginaw (Saginaw)
- MyMichigan Medical Center Tawas (Tawas City)
- Henry Ford West Bloomfield Hospital (West Bloomfield)
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus (Ypsilanti)
-
Minnesota
- Minnesota Oncology Hematology PA-Chaska (Chaska)
- Fairview Clinics and Surgery Center Maple Grove (Maple Grove)
- Hennepin County Medical Center (Minneapolis)
- University of Minnesota/Masonic Cancer Center (Minneapolis)
- Monticello Cancer Center (Monticello)
- Coborn Cancer Center at Saint Cloud Hospital (Saint Cloud)
- Ridgeview Medical Center (Waconia)
-
Mississippi
- University of Mississippi Medical Center (Jackson)
-
Missouri
- Siteman Cancer Center at Saint Peters Hospital (City of Saint Peters)
- MU Health - University Hospital/Ellis Fischel Cancer Center (Columbia)
- Siteman Cancer Center at West County Hospital (Creve Coeur)
- Parkland Health Center - Farmington (Farmington)
- Mercy Hospital Springfield (Springfield)
- Washington University School of Medicine (St Louis)
- Siteman Cancer Center-South County (St Louis)
- Siteman Cancer Center at Christian Hospital (St Louis)
-
Nebraska
- Nebraska Medicine-Bellevue (Bellevue)
- Nebraska Medicine-Village Pointe (Omaha)
- University of Nebraska Medical Center (Omaha)
-
Nevada
- Renown Regional Medical Center (Reno)
-
New Jersey
- Memorial Sloan Kettering Basking Ridge (Basking Ridge)
- Jefferson Cherry Hill Hospital (Cherry Hill)
- Saint Barnabas Medical Center (Livingston)
- Memorial Sloan Kettering Monmouth (Middletown)
- Memorial Sloan Kettering Bergen (Montvale)
- Jersey Shore Medical Center (Neptune City)
- Rutgers Cancer Institute of New Jersey (New Brunswick)
- Rutgers New Jersey Medical School (Newark)
- Newark Beth Israel Medical Center (Newark)
- The Valley Hospital - Luckow Pavilion (Paramus)
- Valley Health System Ridgewood Campus (Ridgewood)
- Sidney Kimmel Cancer Center Washington Township (Sewell)
- and 2 more in New Jersey
-
New Mexico
- University of New Mexico Cancer Center (Albuquerque)
-
New York
- New York-Presbyterian/Brooklyn Methodist Hospital (Brooklyn)
- NYU Langone Hospital - Brooklyn (Brooklyn)
- Memorial Sloan Kettering Commack (Commack)
- The New York Hospital Medical Center of Queens (Flushing)
- Memorial Sloan Kettering Westchester (Harrison)
- Northwell Health/Center for Advanced Medicine (Lake Success)
- NYU Langone Hospital - Long Island (Mineola)
- Mount Sinai Chelsea (New York)
- Laura and Isaac Perlmutter Cancer Center at NYU Langone (New York)
- Mount Sinai West (New York)
- Mount Sinai Hospital (New York)
- Manhattan Eye Ear and Throat Hospital (New York)
- and 12 more in New York
-
North Dakota
- Sanford Broadway Medical Center (Fargo)
- Sanford Roger Maris Cancer Center (Fargo)
-
Ohio
- UH Seidman Cancer Center at UH Avon Health Center (Avon)
- Indu and Raj Soin Medical Center (Beavercreek)
- University of Cincinnati Cancer Center-UC Medical Center (Cincinnati)
- Case Western Reserve University (Cleveland)
- Ohio State University Comprehensive Cancer Center (Columbus)
- Riverside Methodist Hospital (Columbus)
- Grant Medical Center (Columbus)
- Delaware Health Center-Grady Cancer Center (Delaware)
- Grady Memorial Hospital (Delaware)
- Kettering Medical Center (Kettering)
- UH Seidman Cancer Center at Lake Health Mentor Campus (Mentor)
- University of Cincinnati Cancer Center-West Chester (West Chester)
- and 1 more in Ohio
-
Oklahoma
- University of Oklahoma Health Sciences Center (Oklahoma City)
-
Oregon
- Clackamas Radiation Oncology Center (Clackamas)
- Legacy Mount Hood Medical Center (Gresham)
- Legacy Good Samaritan Hospital and Medical Center (Portland)
- Providence Portland Medical Center (Portland)
- Providence Saint Vincent Medical Center (Portland)
- Legacy Meridian Park Hospital (Tualatin)
-
Pennsylvania
- Saint Luke's Cancer Center - Allentown (Allentown)
- Saint Luke's University Hospital-Bethlehem Campus (Bethlehem)
- Chambersburg Hospital (Chambersburg)
- Northeast Radiation Oncology Center (Dunmore)
- Saint Luke's Hospital-Anderson Campus (Easton)
- Penn State Milton S Hershey Medical Center (Hershey)
- NRG Oncology (Philadelphia)
- University of Pennsylvania/Abramson Cancer Center (Philadelphia)
- Thomas Jefferson University Hospital (Philadelphia)
- Jefferson Torresdale Hospital (Philadelphia)
- UPMC-Presbyterian Hospital (Pittsburgh)
- UPMC-Shadyside Hospital (Pittsburgh)
- and 5 more in Pennsylvania
-
Quebec
- CHUM - Centre Hospitalier de l'Universite de Montreal (Montreal)
- The Research Institute of the McGill University Health Centre (MUHC) (Montreal)
-
South Carolina
- Saint Francis Hospital (Greenville)
- Saint Francis Cancer Center (Greenville)
-
South Dakota
- Sanford Cancer Center Oncology Clinic (Sioux Falls)
- Sanford USD Medical Center - Sioux Falls (Sioux Falls)
-
Tennessee
- Vanderbilt Breast Center at One Hundred Oaks (Nashville)
- Vanderbilt University/Ingram Cancer Center (Nashville)
-
Texas
- MD Anderson in The Woodlands (Conroe)
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center (Houston)
- Memorial Hermann Texas Medical Center (Houston)
- UT MD Anderson Cancer Center (Houston)
- MD Anderson West Houston (Houston)
- UT MD Anderson - League City (League City)
- University of Texas Health Science Center at San Antonio (San Antonio)
- MD Anderson in Sugar Land (Sugar Land)
-
Utah
- Huntsman Cancer Institute/University of Utah (Salt Lake City)
-
Vermont
- University of Vermont Medical Center (Burlington)
- University of Vermont and State Agricultural College (Burlington)
-
Virginia
- University of Virginia Cancer Center (Charlottesville)
- VCU Massey Comprehensive Cancer Center (Richmond)
-
Washington
- Valley Medical Center (Renton)
- Legacy Cancer Institute Medical Oncology and Day Treatment (Vancouver)
- Legacy Salmon Creek Hospital (Vancouver)
-
Wisconsin
- Langlade Hospital and Cancer Center (Antigo)
- ThedaCare Regional Cancer Center (Appleton)
- Gundersen Lutheran Medical Center (La Crosse)
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center (Madison)
- University of Wisconsin Carbone Cancer Center - University Hospital (Madison)
- Medical College of Wisconsin (Milwaukee)
- Aspirus Cancer Care - James Beck Cancer Center (Rhinelander)
- Aspirus Cancer Care - Stevens Point (Stevens Point)
- Aspirus Regional Cancer Center (Wausau)
- Aspirus Cancer Care - Wisconsin Rapids (Wisconsin Rapids)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.