Testing the drug AMXT 1501 with eflornithine (DFMO) for neuroblastoma, brain and spinal cord tumors, and sarcomas
Official title: Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study is testing an experimental pill, AMXT 1501, taken together with a pill called eflornithine (DFMO).
Read our full plain-language summary
What the trial team says
The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one that has not been approved by the U.S. Food \& Drug Administration (FDA), or any other regulatory authorities around the world for use alone or in combination with any drug, for the condition or illness it is being used to treat. The goals of this part of the study are: * Establish a recommended dose of AMXT 1501 in combination with DFMO * Test the safety and tolerability of AMXT 1501 in combination with DFMO * To determine the activity of study treatments chosen based on: * How each subject responds to the study treatment * How long a subject lives without their disease returning/progressing
Key facts
- Registry number
- NCT06465199
- Stage of testing
- Phase 1/Phase 2
- Conditions studied
- Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes, Ewing Sarcoma, Diffuse Intrinsic Pontine Glioma, Osteosarcoma, Neuroblastoma, DIPG Brain Tumor
Where it is running
This trial lists 14 sites.
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Alabama
- University of Alabama/Children's of Alabama (Birmingham)
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Arkansas
- Arkansas Children's Hospital (Little Rock)
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Connecticut
- Connecticut Children's Hospital (Hartford)
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Florida
- University of Florida (Gainesville)
- Nicklaus Children's Hospital (Miami)
- Arnold Palmer Hospital for Children (Orlando)
- St. Joseph's Children's Hospital (Tampa)
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Hawaii
- Kapiolani Medical Center for Women and Children (Honolulu)
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Kansas
- Children's Mercy Hospitals and Clinics (Kansas City)
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Missouri
- Cardinal Glennon Children's Medical Center (St Louis)
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New Jersey
- Hackensack University Medical Center (Hackensack)
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Pennsylvania
- Penn State Milton S. Hershey Medical Center and Children's Hospital (Hershey)
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Tennessee
- Monroe Carrell Jr. Children's Hospital at Vanderbilt (Nashville)
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Texas
- Children's Medical Center (Dallas)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.