Testing olutasidenib with temozolomide for young people with IDH1-mutant high-grade glioma
Official title: Study of Olutasidenib and Temozolomide in HGG
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study tests whether adding a drug called olutasidenib to temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary helps young people with a certain kind of brain tumor live longer.
Read our full plain-language summary
What the trial team says
The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation. The main question the study aims to answer is whether the combination of olutasidenib and temozolomide (TMZ) can prolong the life of patients diagnosed with an IDH-mutant HGG.
Key facts
- Registry number
- NCT06161974
- Stage of testing
- Phase 2
- Conditions studied
- High Grade Glioma, Astrocytoma, Astrocytoma, Grade III, Astrocytoma, Grade IV, Diffuse Intrinsic Pontine Glioma, WHO Grade III Glioma, WHO Grade IV Glioma, Metastatic Brain Tumor, Diffuse Midline Glioma, H3 K27M-Mutant, Thalamus Tumor, Spinal Tumor, IDH1 Mutation, IDH1 R132, IDH1 R132C, IDH1 R132H, IDH1 R132S, IDH1 R132G, IDH1 R132L, Oligodendroglioma
Where it is running
This trial lists 20 sites.
-
Baden-Wurttemberg
- Hopp Children's Cancer Center at NCT Heidelberg (KiTZ) (Heidelberg)
-
Colorado
- Children's Hospital Colorado (Aurora)
-
District of Columbia
- Children's National Medical Center (Washington D.C.)
-
Florida
- University of Miami Hospital and Clinics (Miami)
-
Grafton
- Starship Children's Hospital (Auckland)
-
Illinois
- Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago)
-
Massachusetts
- Susan Chi (Boston)
-
Netherlands
- Princess Máxima Center (Utrecht)
-
New South Wales
- Sydney Children's Hospital (Randwick)
-
North Carolina
- Duke University Health System (Durham)
-
Ohio
- Cincinnati Children's Hospital Medical Center (Cincinnati)
- Nationwide Children's Hospital (Columbus)
-
Ontario
- The Hospital for Sick Children (SickKids) (Toronto)
-
Pennsylvania
- Children's Hospital of Philadelphia (Philadelphia)
-
Quebec
- Montreal Children's Hospital (Montreal)
-
Queensland
- Queensland Children's Hospital (South Brisbane)
-
Texas
- Texas Children's Hospital (Houston)
-
United Kingdom
- Great Ormond Street Hospital (London)
-
Washington
- Seattle Children's Hospital (Seattle)
-
Western Australia
- Perth Children's Hospital (Perth)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.