Testing a faster brain scan to tell tumor regrowth from radiation damage
Official title: Development of MRF for Characterization of Brain Tumors After Radiotherapy
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
Researchers are testing a new kind of MRI scan to see if it can tell a tumor that came back apart from damage caused by past radiation.
Read our full plain-language summary
What the trial team says
The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short scan time of 5 min for viewing the entire brain. This is an advanced quantitative assessment of brain tissues. This method is being applied with IVIM MRI to be able to tell the difference between a brain with radiation necrosis and a brain with tumor recurrence. Participants will consist of individuals who have received radiation therapy in the past and were diagnosed with radiation necrosis, individuals with recurrent tumors, individuals with previously untreated tumors, and healthy individuals who have no brain diseases and have not had radiation treatment to the brain. Participants will undergo an MRI scan at a one-time research study visit; no extra tests or procedures will be required for this research study. The primary objectives of this study are: * To demonstrate the clinical feasibility of combining MRF with state-of-the-art parallel imaging techniques to achieve high-resolution quantitative imaging within a reasonable scan time of 5 min for whole brain coverage. * To apply the developed quantitative approach in combination with IVIM MRI for differentiation of tumor recurrence and radiation necrosis. * To investigate the effect of radiation dose on the development of radiation necrosis and tumor recurrence.
Key facts
- Registry number
- NCT06101069
- Stage of testing
- Not applicable
- Conditions studied
- Brain Tumor, Brain Necrosis, Brain Metastases, Glioma
Where it is running
This trial lists 2 sites.
-
Ohio
- University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center (Cleveland)
- Cleveland Clinic Taussig Cancer Center (Cleveland)
How to use this
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Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.