A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
What the trial team says
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.
Key facts
- Registry number
- NCT05538130
- Stage of testing
- Phase 1
- Conditions studied
- Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Advanced or Metastatic Solid Tumors, HGG, LGG, Low Grade Glioma, High Grade Glioma, Differentiated Thyroid Cancer, NSCLC (Non-small Cell Lung Cancer)
Where it is running
This trial lists 83 sites.
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Alabama
- The Kirklin Clinic of UAB Hospital (Birmingham)
- The University of Alabama at Birmingham (Birmingham)
- University of Alabama at Birmingham - Phase I Clinical Trials Unit (Birmingham)
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Alberta
- Cross Cancer Institute (Edmonton)
- Alberta Health Services and The Governors of The University of Alberta (Edmonton)
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Arkansas
- Highlands Oncology Group, PA (Fayetteville)
- Highlands Oncology Group, PA (Rogers)
- Highlands Oncology Group, PA (Springdale)
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Brazil
- Centro de Oncologia - CEON+ - Unidade São Caetano do Sul (São Caetano do Sul)
- IBCC - Núcleo de Pesquisa e Ensino (São Paulo)
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California
- The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate (Los Angeles)
- Keck Hospital of USC (Los Angeles)
- Los Angeles General Medical Center (Los Angeles)
- USC/Norris Comprehensive Cancer Center (Los Angeles)
- Keck Medical Center of USC Pasadena (Pasadena)
- UCSF Helen Diller Family Comprehensive Cancer Center (San Francisco)
- UCSF Helen Diller Medical Center at Parnassus Heights (San Francisco)
- UCSF Medical Center, Investigational Pharmacy (San Francisco)
- The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only) (Santa Monica)
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Central District
- Rabin Medical Center (Petah Tikva)
- Sheba Medical Center (Ramat Gan)
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Chiba
- National Cancer Center Hospital East (Kashiwa)
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Florida
- Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center (Tampa)
- Moffitt Cancer Center (Tampa)
- Moffitt McKinley Hospital (Tampa)
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Fujian
- Fujian Cancer Hospital (Fuzhou)
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Jerusalem
- Hadassah Medical Center (Jerusalem)
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Louisiana
- Ochsner Clinic Foundation (New Orleans)
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Massachusetts
- Massachusetts General Hospital (Boston)
- Ophthalmic Consultants of Boston Inc (OCB) (Boston)
- Brigham and Women's Hospital (Boston)
- Dana-Farber Cancer Institute (Boston)
- Mass General Waltham (Waltham)
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Michigan
- Brigitte Harris Cancer Pavilion (Detroit)
- Henry Ford Hospital (Detroit)
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Minnesota
- HealthPartners Frauenshuh Cancer Center (Saint Louis Park)
- Methodist Hospital Inpatient Pharmacy (Saint Louis Park)
- HealthPartners Cancer Center at regions Hospital (Saint Paul)
- Regions Hospital Pharmacy (Saint Paul)
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New Jersey
- MSK Basking Ridge. (Basking Ridge)
- MSK Monmouth. (Middletown)
- MSK Bergen. (Montvale)
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New York
- Optum Medical Care, PC (Brewster)
- MSK Commack. (Commack)
- MSK Westchester. (Harrison)
- Optum Medical Care, PC (Mount Kisco)
- Laura & Isaac Perlmutter Cancer Center - NYU ACC (New York)
- Laura & Isaac Perlmutter Cancer Center at NYU Langone Health (New York)
- NYU Langone Faculty Group Practice (New York)
- NYU Langone Medical Center (Tisch Hospital) (New York)
- Memorial Sloan Kettering Cancer Center 53rd street. (New York)
- Columbia University Irving Medical Center (New York)
- Columbia University Medical Center - Neurological Institute of New York (New York)
- CUIMC Research Pharmacy (New York)
- and 2 more in New York
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Ohio
- Cleveland Clinic Taussig Cancer Center Investigational Pharmacy (Cleveland)
- Cleveland Clinic Taussig Cancer Center (Cleveland)
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Ontario
- The Ottawa Hospital - General Campus (Ottawa)
- Sunnybrook Research Institute (Toronto)
- Princess Margaret Cancer Centre (Toronto)
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Oregon
- Providence Cancer Institute Franz Clinic (Portland)
- Providence Portland Medical Center (Portland)
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Osaka
- Kansai Medical University Hospital (Hirakata)
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Pennsylvania
- UPMC Hillman Cancer Center (Pittsburgh)
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Quebec
- Jewish General Hospital (Montreal)
- McGill University Health Centre (Montreal)
- Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus (Québec)
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Rio Grande do Sul
- Hospital Nossa Senhora da Conceição (Porto Alegre)
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Santa Catarina
- ANIMI - Unidade de Tratamento Oncologico (Lages)
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Southern District
- Soroka Medical Center (Beersheba)
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TELL ABĪB
- Sourasky Medical Center (Tel Aviv)
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Tennessee
- SCRI Oncology Partners (Nashville)
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Texas
- University of Texas MD Anderson Cancer Center (Houston)
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Victoria
- Peter MacCallum Cancer Centre (Melbourne)
- The Alfred Hospital (Melbourne)
- Royal Melbourne Hospital (Parkville)
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Washington
- Fred Hutchinson Cancer Center (Seattle)
- University of Washington Medical Center (Seattle)
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Wisconsin
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center (Madison)
- University of Wisconsin Carbone Cancer Center - University Hospital (Madison)
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Zhejiang
- Zhejiang Cancer Hospital (Hangzhou)
- The First Affiliated Hospital of Wenzhou Medical University (Wenzhou)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.