Testing selinexor added to usual chemotherapy for glioblastoma that has come back
Official title: Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study is testing whether adding a drug called selinexor to the usual chemotherapy helps people whose brain tumor has returned.
Read our full plain-language summary
What the trial team says
This phase I/II trial tests the safety, side effects and best dose of selinexor given in combination with the usual chemotherapy (temozolomide) and compares the effect of this combination therapy versus the usual chemotherapy alone (temozolomide) in treating patients with glioblastoma that has come back (recurrent). Selinexor is in a class of medications called selective inhibitors of nuclear export (SINE). It works by blocking a protein called CRM1, which may keep cancer cells from growing and may kill them. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Giving selinexor in combination with usual chemotherapy (temozolomide) may shrink or stabilize the tumor better than the usual chemotherapy with temozolomide alone in patients with recurrent glioblastoma.
Key facts
- Registry number
- NCT05432804
- Stage of testing
- Phase 1/Phase 2
- Conditions studied
- Recurrent Glioblastoma, IDH-Wildtype, Recurrent MGMT-Methylated Glioblastoma
Where it is running
This trial lists 36 sites.
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Arizona
- Mayo Clinic Hospital in Arizona (Phoenix)
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California
- City of Hope Comprehensive Cancer Center (Duarte)
- UC San Diego Moores Cancer Center (La Jolla)
- Keck Medicine of USC Koreatown (Los Angeles)
- Los Angeles General Medical Center (Los Angeles)
- USC / Norris Comprehensive Cancer Center (Los Angeles)
- University of California Davis Comprehensive Cancer Center (Sacramento)
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Colorado
- UCHealth University of Colorado Hospital (Aurora)
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Florida
- UM Sylvester Comprehensive Cancer Center at Coral Gables (Coral Gables)
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach (Deerfield Beach)
- Mayo Clinic in Florida (Jacksonville)
- University of Miami Miller School of Medicine-Sylvester Cancer Center (Miami)
- Moffitt Cancer Center (Tampa)
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Georgia
- Emory University Hospital Midtown (Atlanta)
- Emory University Hospital/Winship Cancer Institute (Atlanta)
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Illinois
- University of Chicago Comprehensive Cancer Center (Chicago)
- University of Chicago Medicine-Orland Park (Orland Park)
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Kentucky
- University of Kentucky/Markey Cancer Center (Lexington)
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Minnesota
- Mayo Clinic in Rochester (Rochester)
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New Jersey
- Cooperman Barnabas Medical Center (Livingston)
- Rutgers Cancer Institute of New Jersey (New Brunswick)
- Rutgers New Jersey Medical School (Newark)
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New York
- Roswell Park Cancer Institute (Buffalo)
- Laura and Isaac Perlmutter Cancer Center at NYU Langone (New York)
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center (New York)
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North Carolina
- Wake Forest University Health Sciences (Winston-Salem)
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Ohio
- University of Cincinnati Cancer Center-UC Medical Center (Cincinnati)
- Ohio State University Comprehensive Cancer Center (Columbus)
- University of Cincinnati Cancer Center-West Chester (West Chester)
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Oklahoma
- University of Oklahoma Health Sciences Center (Oklahoma City)
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Pennsylvania
- UPMC Hillman Cancer Center (Pittsburgh)
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Utah
- Huntsman Cancer Institute/University of Utah (Salt Lake City)
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Virginia
- University of Virginia Cancer Center (Charlottesville)
- VCU Massey Comprehensive Cancer Center (Richmond)
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Wisconsin
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center (Madison)
- University of Wisconsin Carbone Cancer Center - University Hospital (Madison)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.