A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
What the trial team says
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines in people with solid tumors. This study is seeking participants who have an advanced solid tumor with a certain type of abnormal gene called "BRAF" and available treatments are no longer effective in controlling their cancer. All participants in this study will receive PF-07799933. PF-07799933 comes as a tablet to take by mouth, 2 times a day. Depending on the part of the study, participants may also receive another study medicine: * People with melanoma or other solid tumors may also receive binimetinib. Binimetinib comes as a tablet to take by mouth, 2 times a day. * People with colorectal cancer may also receive cetuximab or cetuximab and mFOLFOX6 (Chemotherapy regimen). Cetuximab will be given weekly (or every two weeks) in the clinic as a shot given in the vein or port (intravenous, IV). Participants may receive the study medicines for about 2 years. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.
Key facts
- Registry number
- NCT05355701
- Stage of testing
- Phase 1
- Conditions studied
- Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma, Advanced Colorectal Cancer (Part 1)
Where it is running
This trial lists 40 sites.
-
Arkansas
- Highlands Oncology Group, PA (Fayetteville)
- Highlands Oncology Group, PA (Rogers)
- Highlands Oncology Group, PA (Springdale)
-
Central District
- Sourasky Medical Center (Tel Aviv)
-
Colorado
- Clinical and Translational Research Center (CTRC) (Aurora)
- UCHealth Sue Anschutz-Rodgers Eye Center (Aurora)
- University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) (Aurora)
- University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) (Aurora)
- University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP) (Aurora)
-
Florida
- Sylvester Comprehensive Cancer Center (Miami)
- University of Miami Hospital and Clinics (Miami)
-
Israel
- Hadassah Medical Center (Jerusalem)
- Sheba Medical Center (Ramat Gan)
-
Massachusetts
- Brigham and Women's Hospital (Boston)
- Dana-Farber Cancer Institute (Boston)
- Dana-Farber Cancer Institute - Chestnut Hill (Newton)
-
Michigan
- Brigitte Harris Cancer Pavilion (Detroit)
- Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion) (Detroit)
- Henry Ford Medical Center - Columbus (Novi)
- CT Scan and Echo Only: Henry Ford Medical Center-Plymouth (Plymouth)
-
New Jersey
- MSK Monmouth (Middletown)
-
New York
- MSK David H. Koch Center for Cancer Care (New York)
- Memorial Sloan Kettering Cancer Center 53rd street (New York)
- Memorial Sloan Kettering Cancer Center (New York)
-
Ohio
- Cleveland Clinic Taussig Cancer Center Investigational Pharmacy (Cleveland)
- Cleveland Clinic (Cleveland)
-
Ontario
- The Ottawa Hospital - General Campus (Ottawa)
- Princess Margaret Cancer Centre (Toronto)
- University Health Network (Toronto)
-
Oregon
- Providence Cancer Institute Franz Clinic (Portland)
- Providence Portland Medical Center (Portland)
-
Quebec
- Jewish General Hospital (Montreal)
- McGill University Health Centre (Montreal)
-
Tennessee
- Sarah Cannon Research Institute - Pharmacy (Nashville)
- SCRI Oncology Partners (Nashville)
- TriStar Bone Marrow Transplant (Nashville)
- TriStar Centennial Medical Center - Cell Processing Lab (Nashville)
- TriStar Centennial Medical center (Nashville)
-
Texas
- START San Antonio (San Antonio)
-
Ḥeifā
- Rambam Health Care Campus (Haifa)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.