Testing metformin for thinking and brain growth in children after brain tumor treatment
Official title: Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This trial tests a drug called metformin in young people who finished brain tumor treatment.
Read our full plain-language summary
What the trial team says
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind placebo-controlled parallel arm superiority trial. Specifically, in children/adolescents aged 7 years to 21 years and 11 months who have completed treatment for a brain tumour, is oral administration of metformin for 16 weeks associated with greater improvement of cognitive function and brain growth compared to placebo administered for 16 weeks?
Key facts
- Registry number
- NCT05230758
- Stage of testing
- Phase 3
- Conditions studied
- Medulloblastoma, Childhood, Cognitive Impairment
Where it is running
This trial lists 20 sites.
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Alberta
- Alberta Children's Hospital (Calgary)
- Stollery Children's Hospital (Edmonton)
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British Columbia
- Children's & Women's Health Centre of British Columbia (Vancouver)
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Manitoba
- Cancer Care Manitoba (Winnipeg)
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New South Wales
- John Hunter Children's Hospital (New Lambton Heights)
- Children's Hospital in Westmead (Westmead)
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North Adelaide
- Women and Childen's Hospital (Adelaide)
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Nova Scotia
- Izaak Walton Killam (IWK) Health Centre (Halifax)
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Ontario
- Hamilton Health Sciences - McMaster Children's Hospital (Hamilton)
- Children's Hospital, London Health Sciences Centre (London)
- Children's Hospital of Eastern Ontario (Ottawa)
- The Hospital for Sick Children (Toronto)
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Quebec
- CHU Sainte-Justine (Montreal)
- Montreal Children's Hospital (Montreal)
- CHU de Québec - Université Laval (Québec)
- CHU de Sherbrooke (Sherbrooke)
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Saskatchewan
- Saskatchewan Health Authority (Saskatoon)
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Victoria
- Monash Children's Hospital (Clayton)
- Royal Children's Hospital (Parkville)
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Western Australia
- Perth Children's Hospital (Nedlands)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.