A vaccine called PEP-CMV for children with certain brain tumors
Official title: PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study tests a vaccine in children with high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary, DIPG, or medulloblastoma that has come back.
Read our full plain-language summary
What the trial team says
This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, and antibody epitopes across several haplotypes. Component A will be administered as a stable water:oil emulsion in Montanide ISA 51. Funding Source - FDA OOPD
Key facts
- Registry number
- NCT05096481
- Stage of testing
- Phase 2
- Conditions studied
- High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma
Where it is running
This trial lists 13 sites.
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Colorado
- Children's Hospital Colorado (Aurora)
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District of Columbia
- Children's National Medical Center (Washington D.C.)
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Florida
- Nicklaus Children's Hospital (Miami)
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Illinois
- Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago)
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Massachusetts
- Dana-Farber Cancer Institute (Boston)
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Michigan
- C.S. Mott Children's Hospital (Ann Arbor)
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Missouri
- St. Louis Children's Hospital (St Louis)
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North Carolina
- Duke Cancer Center (Durham)
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Ohio
- Cincinnati Children's Hospital Medical Center (Cincinnati)
- Nationwide Children's Hospital (Columbus)
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Pennsylvania
- Children's Hospital of Philadelphia (Philadelphia)
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Texas
- Texas Children's Hospital (Houston)
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Washington
- Seattle Children's Hospital (Seattle)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.