Testing the drug CBL0137 in people whose tumors came back or did not respond to treatment
Official title: CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study is testing a drug called CBL0137 in people with solid tumors, brain and spine tumors, or lymphoma that came back or kept growing.
Read our full plain-language summary
What the trial team says
This phase I/II trial evaluates the best dose, side effects and possible benefit of CBL0137 in treating patients with solid tumors, including central nervous system (CNS) tumors or lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Drugs, such as CBL0137, block signals passed from one molecule to another inside a cell. Blocking these signals can affect many functions of the cell, including cell division and cell death, and may kill cancer cells.
Key facts
- Registry number
- NCT04870944
- Stage of testing
- Phase 1/Phase 2
- Conditions studied
- Diffuse Midline Glioma, H3 K27-Altered, Metastatic Malignant Neoplasm in the Central Nervous System, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Diffuse Midline Glioma, H3 K27-Altered, Recurrent Lymphoma, Recurrent Malignant Solid Neoplasm, Recurrent Primary Malignant Central Nervous System Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm, Refractory Primary Malignant Central Nervous System Neoplasm
Where it is running
This trial lists 35 sites.
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Alabama
- Children's Hospital of Alabama (Birmingham)
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Arizona
- Phoenix Childrens Hospital (Phoenix)
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California
- Children's Hospital Los Angeles (Los Angeles)
- Children's Hospital of Orange County (Orange)
- UCSF Medical Center-Mission Bay (San Francisco)
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Colorado
- Children's Hospital Colorado (Aurora)
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District of Columbia
- Children's National Medical Center (Washington D.C.)
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Florida
- Johns Hopkins All Children's Hospital (St. Petersburg)
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Georgia
- Children's Healthcare of Atlanta - Arthur M Blank Hospital (Atlanta)
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Illinois
- Lurie Children's Hospital-Chicago (Chicago)
- University of Chicago Comprehensive Cancer Center (Chicago)
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Indiana
- Riley Hospital for Children (Indianapolis)
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Maryland
- Johns Hopkins University/Sidney Kimmel Cancer Center (Baltimore)
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Massachusetts
- Dana-Farber Cancer Institute (Boston)
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Michigan
- C S Mott Children's Hospital (Ann Arbor)
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Minnesota
- University of Minnesota/Masonic Cancer Center (Minneapolis)
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Missouri
- Children's Mercy Hospitals and Clinics (Kansas City)
- Washington University School of Medicine (St Louis)
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New South Wales
- Sydney Children's Hospital (Randwick)
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New York
- Roswell Park Cancer Institute (Buffalo)
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center (New York)
- Memorial Sloan Kettering Cancer Center (New York)
- New York Medical College (Valhalla)
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North Carolina
- Duke University Medical Center (Durham)
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Ohio
- Cincinnati Children's Hospital Medical Center (Cincinnati)
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Oregon
- Oregon Health and Science University (Portland)
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Pennsylvania
- Children's Hospital of Philadelphia (Philadelphia)
- Children's Hospital of Pittsburgh of UPMC (Pittsburgh)
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Tennessee
- Saint Jude Children's Research Hospital (Memphis)
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Texas
- UT Southwestern/Simmons Cancer Center-Dallas (Dallas)
- Cook Children's Medical Center (Fort Worth)
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center (Houston)
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Utah
- Primary Children's Hospital (Salt Lake City)
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Washington
- Seattle Children's Hospital (Seattle)
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Wisconsin
- Children's Hospital of Wisconsin (Milwaukee)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.