Adding lenalidomide and nivolumab to the usual drugs for primary CNS lymphoma
Official title: Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This study is testing whether two added drugs can help treat lymphoma in the brain and spinal cord.
Read our full plain-language summary
What the trial team says
This phase I trial tests the safety, side effects, best dose and effectiveness of lenalidomide when added to nivolumab and the usual drugs (rituximab and methotrexate) in patients with primary central nervous system (CNS) lymphoma. Lenalidomide may stop or slow primary CNS lymphoma by blocking the growth of new blood vessels necessary for tumor growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Methotrexate is frequently combined with other chemotherapy agents to improve response. This study may help increase the understanding of lenalidomide and nivolumab use in primary CNS lymphoma treatment. In addition, it may help researchers see whether the control of CNS lymphoma can be extended by using these study drugs as maintenance (prolonged therapy) after control is achieved with the initial chemotherapy regimen (induction).
Key facts
- Registry number
- NCT04609046
- Stage of testing
- Phase 1
- Conditions studied
- Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
Where it is running
This trial lists 55 sites.
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California
- Cedars-Sinai Medical Center (Los Angeles)
- UCSF Medical Center-Parnassus (San Francisco)
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Florida
- UM Sylvester Comprehensive Cancer Center at Coral Gables (Coral Gables)
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach (Deerfield Beach)
- University of Miami Miller School of Medicine-Sylvester Cancer Center (Miami)
- UM Sylvester Comprehensive Cancer Center at Kendall (Miami)
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia (North Miami)
- UM Sylvester Comprehensive Cancer Center at Plantation (Plantation)
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Iowa
- UI Health Care Mission Cancer and Blood - Ankeny Clinic (Ankeny)
- Saint Anthony Regional Hospital (Carroll)
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic (Clive)
- Iowa Methodist Medical Center (Des Moines)
- UI Health Care Mission Cancer and Blood - Des Moines Clinic (Des Moines)
- Broadlawns Medical Center (Des Moines)
- Mercy Medical Center - Des Moines (Des Moines)
- UI Health Care Mission Cancer and Blood - Laurel Clinic (Des Moines)
- Iowa Lutheran Hospital (Des Moines)
- UI Healthcare Mission Cancer and Blood - Fort Dodge (Fort Dodge)
- University of Iowa/Holden Comprehensive Cancer Center (Iowa City)
- UI Health Care Mission Cancer and Blood - Waukee Clinic (Waukee)
- and 1 more in Iowa
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Louisiana
- LSU Health Baton Rouge-North Clinic (Baton Rouge)
- Our Lady of the Lake Physician Group (Baton Rouge)
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Maine
- MaineHealth Maine Medical Center - Portland (Portland)
- MaineHealth Maine Medical Center- Scarborough (Scarborough)
- MaineHealth Cancer Care and IV Therapy - South Portland (South Portland)
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Michigan
- Hickman Cancer Center (Adrian)
- Toledo Clinic Cancer Centers-Monroe (Monroe)
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Missouri
- Siteman Cancer Center at Saint Peters Hospital (City of Saint Peters)
- Siteman Cancer Center at West County Hospital (Creve Coeur)
- Washington University School of Medicine (St Louis)
- Siteman Cancer Center-South County (St Louis)
- Siteman Cancer Center at Christian Hospital (St Louis)
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New Jersey
- Overlook Hospital (Summit)
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New York
- Northwell Health/Center for Advanced Medicine (Lake Success)
- North Shore University Hospital (Manhasset)
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center (New York)
- NYP/Weill Cornell Medical Center (New York)
- State University of New York Upstate Medical University (Syracuse)
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North Carolina
- UNC Lineberger Comprehensive Cancer Center (Chapel Hill)
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Ohio
- Ohio State University Comprehensive Cancer Center (Columbus)
- Toledo Clinic Cancer Centers-Toledo (Toledo)
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Oklahoma
- University of Oklahoma Health Sciences Center (Oklahoma City)
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Rhode Island
- Rhode Island Hospital (Providence)
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South Carolina
- Medical University of South Carolina (Charleston)
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Texas
- UT Southwestern/Simmons Cancer Center-Dallas (Dallas)
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Utah
- Huntsman Cancer Institute/University of Utah (Salt Lake City)
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West Virginia
- West Virginia University Healthcare (Morgantown)
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Wisconsin
- Marshfield Medical Center-EC Cancer Center (Eau Claire)
- Gundersen Lutheran Medical Center (La Crosse)
- Marshfield Medical Center-Marshfield (Marshfield)
- Marshfield Medical Center - Minocqua (Minocqua)
- Marshfield Medical Center-Rice Lake (Rice Lake)
- Marshfield Medical Center-River Region at Stevens Point (Stevens Point)
- Marshfield Medical Center - Weston (Weston)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.