Testing two drugs together for gliomas that came back in kids and young adults
Official title: Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
The short version
This trial tests whether two drugs used together work better against a glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary that has come back.
Read our full plain-language summary
What the trial team says
This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth. Everolimus is a drug that may block another pathway in tumor cells that can help tumors grow. Giving trametinib and everolimus may work better to treat low and high-grade gliomas compared to trametinib or everolimus alone.
Key facts
- Registry number
- NCT04485559
- Stage of testing
- Phase 1
- Conditions studied
- Recurrent World Health Organization (WHO) Grade II Glioma, Low-grade Glioma, High-Grade Glioma (HGG)
Where it is running
This trial lists 17 sites.
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Alabama
- University of Alabama at Birmingham, Children's of Alabama (Birmingham)
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California
- Children's Hospital Los Angeles (Los Angeles)
- University of California, San Diego Rady Children's Hospital (San Diego)
- University of California, San Francisco (San Francisco)
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District of Columbia
- Children's National Medical Center (Washington D.C.)
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Florida
- University of Florida (Gainesville)
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Illinois
- Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago)
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Indiana
- Riley Hospital for Children (Indianapolis)
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Maryland
- John Hopkins University (Baltimore)
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Massachusetts
- Dana Farber Cancer Institute (Boston)
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Minnesota
- Children's Minnesota (Minneapolis)
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Missouri
- Washington University in St. Louis (St Louis)
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New Jersey
- Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center (Hackensack)
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New York
- New York University (New York)
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Oregon
- Doernbecher Children's Hospital Oregon Health & Science University (Portland)
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Pennsylvania
- Children's Hospital of Philadelphia (Philadelphia)
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Texas
- University Of Texas Southwestern Medical Center (Dallas)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.