A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on .
What the trial team says
Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring anaplastic lymphoma kinase (ALK), receptor tyrosine kinase encoded by the gene ROS1 (ROS1), or neurotrophic receptor kinase genes encoding TRK kinase family (NTRK1-3) alterations to estimate the Maximum Tolerated Dose (MTD) or Maximum Administered Dose (MAD) and select the Pediatric Recommended Phase 2 Dose (RP2D). Phase 2 will determine the anti-tumor activity of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring ROS1 or NTRK1-3 alterations.
Key facts
- Registry number
- NCT04094610
- Stage of testing
- Phase 1/Phase 2
- Conditions studied
- Locally Advanced Solid Tumors, Metastatic Solid Tumors, Lymphoma, Primary CNS Tumors
Where it is running
This trial lists 68 sites.
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Alberta
- University Of Calgary (Calgary)
- Stollery Children'S Hospital (Edmonton)
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Barcelona
- Hospital Sant Joan De Deu (Esplugues de Llobregat)
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California
- Children's Hospital Los Angeles (Los Angeles)
- University of California at Los Angeles (Los Angeles)
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Colorado
- Children's Hospital Colorado - Anschutz Medical Campus (Aurora)
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Denmark
- Rigshospitalet - Glostrup (Copenhagen)
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England
- Alder Hey Children's NHS Foundation Trust (Liverpool)
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Florida
- Local Institution - 2105 (Orlando)
- Local Institution - 2120 (Orlando)
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France
- Centre Hospitalier Universitaire D'Angers (Angers)
- Centre Hospitalier Universitaire de Bordeaux - Groupe Hospitalier Pellegrin (Bordeaux)
- Institut d Hematologie et d Oncologie Pediatriques (Lyon)
- Hôpitaux Universitaires de Marseille Timone (Marseille)
- Local Institution - 6110 (Marseille)
- Local Institution - 6112 (Nantes)
- Local Institution - 6109 (Paris)
- Institut Gustave-Roussy (Villejuif)
- Local Institution - 6108 (Villejuif)
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Georgia
- Children's Healthcare of Atlanta - Egleston Hospital (Atlanta)
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Italy
- Fondazione IRCCS - Istituto Nazionale dei Tumori (Milan)
- Local Institution - 6113 (Padova)
- Local Institution - 4302 (Rome)
- Local Institution - 6114 (Torino)
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Maine
- Maine Medical Center (Scarborough)
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Massachusetts
- Dana Farber Cancer Institute. (Boston)
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Missouri
- Washington University School of Medicine in St. Louis (St Louis)
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Navarre
- Clínica Universidad de navarra (Pamplona)
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New Jersey
- Local Institution - 2110 (New Brunswick)
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New South Wales
- Local Institution - 6104 (Randwick)
- Local Institution - 6103 (Westmead)
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New York
- Local Institution - 2102 (New York)
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North Carolina
- Levine Children's Hospital- Pediatric Neuro-Oncology (Charlotte)
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Ohio
- Local Institution - 2112 (Cleveland)
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Ontario
- Children'S Hospital Of Eastern Ontario (Ottawa)
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Pennsylvania
- Local Institution - 2114 (Hershey)
- Children's Hospital of Philadelphia-Center for Childhood Cancer Research (Philadelphia)
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Quebec
- St Justine Hospital (Montreal)
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Queensland
- Children's Health Queensland Hospital and Health Service (South Brisbane)
-
Rhone
- Local Institution - 6111 (Lyon)
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Seodaemun-gu
- Local Institution - 6303 (Seoul)
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Singapore
- National University Hospital (Singapore)
- KK Women's and Children's Hospital (Singapore)
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South Korea
- Seoul National University Hospital (Seoul)
- Asan Medical Center (Seoul)
- Local Institution - 6304 (Seoul)
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Spain
- Local Institution - 6105 (Barcelona)
- Hospital Universitari Vall d'Hebron (Barcelona)
- Hospital Infantil Universitario Nino Jesus (Madrid)
- Local Institution - 6106 (Madrid)
- Clinica Universidad de Navarra (Madrid)
- HM Sanchinarro University Hospital (Madrid)
- Hospital Universitario Virgen del Rocio (Seville)
- Hospital Universitario Y Politecnico La Fe (Valencia)
- Local Institution - 6107 (Valencia)
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Taiwan
- Local Institution - 6202 (Taipei)
- Taipei Medical University Hospital (Taipei)
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Tennessee
- St. Jude Children's Research Hospital (Memphis)
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Texas
- The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center (Dallas)
- Baylor College of Medicine (Houston)
- Local Institution - 2104 (Houston)
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United Kingdom
- Local Institution - 4403 (Birmingham)
- University Hospital of Wales (Cardiff)
- Royal Hosp. for Children (Glasgow)
- The Royal Marsden NHS Foundation Trust (London)
- Great Ormond Street Hospital For Children NHS Foundation Trust (London)
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Virginia
- Children's Hospital of Richmond at VCU (Richmond)
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Western Australia
- Perth Childrens Hospital (Nedlands)
How to use this
Talk to your care team first. They know your history and can tell you whether this trial is worth your time.
Joining a trial is always your choice. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you.
This page is built from the trial's listing on ClinicalTrials.gov, a service of the U.S. National Library of Medicine. That listing is the authority, and it may have changed since we last read it. We do not run this trial and we cannot enroll you in it.