Why some meningioma cells survive radiation, in lab and mouse tests
Original title: Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done on cells in a lab, not in people. It is a very early step.
This was only done with lab cells and in mice, not in people.
The short version
Scientists found one way meningioma cells may fight off radiation, and how it might be blocked.
What was studied. Researchers made meningioma cells that resist radiation, using two separate cell lines. They studied these cells in the lab and in mice to learn how they survive.
What they found. Radiation normally makes tumor cells stop growing, like putting them to sleep. The cells that resisted radiation burned more sugar and built up a waste product called lactate. This set off a chain of signals inside the cells that woke them back up so they could grow again. When the researchers blocked this chain in mice, the tumors became easier to treat with radiation.
What this means, and what it doesn't
What it could mean: This points to a possible new target for drugs. In the future, such a drug might help radiation work better for meningioma. That could help people whose tumors do not respond well to radiation.
What it doesn't mean: This does not mean there is a new treatment you can get. The work was done only with cells in a dish and in mice. It has not been tested in people. Many steps are still needed before this could reach patients, and it is not a cure.
Source: PubMed, September 16, 2026 · Read the original
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