Two Tumor Markers Linked to More Aggressive Meningiomas
Original title: Correlation of VEGF and Ki-67 Expression with Histopathological Features and WHO Grade in Meningioma: A Cross-sectional Study.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This was a study of stored tumor samples from people, not a new treatment.
The short version
Two markers found in tumor tissue may show how aggressive a meningioma is.
What was studied. Doctors looked at 73 stored meningioma tissue samples. They stained each sample for two markers, called VEGF and Ki-67. Then they compared the results with the tumor's grade and how the cells looked.
What they found. Most of the tumors were WHO Grade I (83.6%). Samples with more VEGF were more likely to show dividing cells, growth into nearby brain, and crowded cells. More VEGF also showed up in the higher grade tumors, Grade II and Grade III. Higher Ki-67 went along with a higher tumor grade and other signs of a more aggressive tumor.
What this means, and what it doesn't
What it could mean: Right now, doctors use the tumor grade to judge how a meningioma may act. These two markers might add helpful detail. That could matter most when a tumor sits near the line between grades.
What it doesn't mean: This is not a treatment and it is not a cure. It does not change the care you get today. The study only looked at tissue under a microscope. It did not follow patients to see how they did over time. It was done at one center, and it included only a small number of high grade tumors. More studies are needed before this changes how doctors work.
Source: PubMed, August 1, 2026 · Read the original
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