Testing Two Pills for Frail Older Adults With New Brain Lymphoma
Original title: Zanubrutinib Plus Lenalidomide for Frail Elderly Patients With Newly Diagnosed PCNSL
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage study in people, and it has no answers yet.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests two pills in frail older adults who were just found to have a brain lymphoma.
Who this trial is for. This trial is for frail adults 70 and older with a newly found brain lymphoma called PCNSL. It tests two pills taken together, zanubrutinib and lenalidomide. The plan is to enroll 33 people.
Where it stands. This trial has not reported results. The main thing being measured is how many people have no sign of the cancer left after the first part of treatment. The team will also track side effects and how people do over time. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: Many frail older adults cannot handle the usual strong chemotherapy for this cancer. This study is looking at a pill option instead. Someone who fits this picture could ask their care team about it.
What it doesn't mean: This does not mean these two pills work. A trial is a test, not proven treatment. Being in one is not a promise that it will help you. It is not a cure. Your own doctor cannot give this to you as care yet.
Source: ClinicalTrials.gov, September 24, 2026 · Read the original
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