Testing triapine with temozolomide for glioblastoma that has come back
Original title: Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people to check safety and find the right dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
Doctors are testing a drug called triapine with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that came back.
Who this trial is for. This trial is for people whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary came back after a time of getting better. It tests a drug called triapine given together with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
Where it stands. This is an early test of safety, side effects, and the best dose. Doctors want to learn if the two drugs are safe to give together. The trial has not reported any results yet.
What this means, and what it doesn't
What it could mean: Triapine may slow tumor cells by blocking something they need to grow. temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary damages tumor cells and may help kill them. If your glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back, you could ask your care team if this trial might fit you. Only the trial team can decide who can join.
What it doesn't mean: This trial is a test, not a proven treatment. Being in it does not mean it will help you. It is not a promise of a cure. We do not know yet if these two drugs work well together.
Source: ClinicalTrials.gov, September 9, 2026 · Read the original
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