Testing three drugs together for glioma that has come back
Original title: VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent Glioma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage test in people, and it is not yet care your own doctor can give.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether a mix of three drugs can stop glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary from growing after it returns.
Who this trial is for. This trial is for people whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back, and for adults whose IDH-mutated glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary has come back. It is testing three drugs given together: valproic acid, irinotecan, and simvastatin.
Where it stands. The trial is checking whether tumors stay the same size or get smaller on this drug mix. The trial has not reported results yet. We do not know yet if it works.
What this means, and what it doesn't
What it could mean: This is one more option being tested for glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary that has come back. If you or someone you care for fits this picture, you could ask the care team if this trial makes sense to look into.
What it doesn't mean: A trial is a test, not a proven treatment. Joining one does not mean it will help you. This is not a cure, and no one knows yet if this drug mix works.
Source: ClinicalTrials.gov, September 21, 2026 · Read the original
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