Testing the drug selinexor with radiation for children and young adults with newly diagnosed DIPG or high-grade glioma
Original title: A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people that is still working out a safe dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether adding a drug called selinexor to standard radiation can help shrink these brain tumors.
Who this trial is for. This trial is for children and young adults who were just diagnosed with DIPG or a high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary with a genetic change called H3 K27M. It tests a drug called selinexor given along with standard radiation therapy.
Where it stands. The trial has not reported results. One part is looking for the highest dose of selinexor that can be given without side effects that are too severe. The other part is looking at whether that dose helps shrink these tumors. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: Selinexor blocks a protein called CRM1. Doctors think that may keep tumor cells from growing. They are studying whether pairing it with radiation helps. If you or your child fits what this trial is looking for, you can ask your care team about it. They can say whether it makes sense for your situation.
What it doesn't mean: This does not mean selinexor with radiation is a proven treatment. A trial is a test, not care your own doctor can give you yet. Being in a trial is not a guarantee that it will help. And it is not a promise of a cure.
Source: ClinicalTrials.gov, August 6, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.