Testing the drug Debio 0123 with temozolomide in adults with glioblastoma
Original title: A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, looking mainly at safety and dosing.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing a drug called Debio 0123 added to usual glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary treatment.
Who this trial is for. This trial is for adults with glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary, a kind of brain tumor. It includes people whose tumor has come back or has grown, and people who were just diagnosed. It is testing a drug called Debio 0123 given with a chemotherapy drug called temozolomide. Some people also get radiation.
Where it stands. This trial has not reported results. The first part is looking at side effects and at what dose is safe to use. One group in the study, called Arm B, was stopped for good after the safety committee looked at safety findings in that group. A later part is planned to compare Debio 0123 plus temozolomide with the usual care. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: This is one place researchers are testing a new drug for glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary. If this sounds like it fits your situation, you can ask your care team about it. They can tell you if it makes sense for you and what joining a study would involve.
What it doesn't mean: This does not mean the drug works. A trial is a test, not a proven treatment. Being in a study is not a guarantee that it will help you, and it is not a promise of a cure. It also does not mean you can join. The trial team decides who is a fit.
Source: ClinicalTrials.gov, July 24, 2026 · Read the original
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