Testing the drug atezolizumab in people whose glioblastoma has come back
Original title: A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage test in people, so it is still being studied.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing a drug called atezolizumab in people whose glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has returned.
Who this trial is for. This trial is for people with glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that has come back, and whose tumor has a low number of gene changes. It gives atezolizumab before their main treatment, and it looks for signs in the body that show who the drug may help.
Where it stands. There are no results yet. The trial is measuring whether giving atezolizumab this way helps these patients, and which signs in the body go with that. The answer is not in yet. The trial has not reported results.
What this means, and what it doesn't
What it could mean: If your glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has come back, this is one study that is being run at more than one center. Someone who thinks they may fit could ask their care team about it. The care team can explain whether it makes sense for them.
What it doesn't mean: This does not mean the drug is proven to work. A trial is a test, not a treatment you can count on. Being in a trial is not a guarantee that you will be helped. It is not a promise of a cure. Nothing here says this drug will make anyone live longer or feel better.
Source: ClinicalTrials.gov, July 31, 2026 · Read the original
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