Testing SX-682 with proton radiation for cancer that has spread to the lining of the brain and spine
Original title: A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test of a new drug combination in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether a drug called SX-682, given with a type of radiation, is safe for people whose melanoma or lung cancer has spread to the lining of the brain and spine.
Who this trial is for. This trial is for people with melanoma or non-small cell lung cancer that has spread to the lining of the brain and spinal cord. It tests a drug called SX-682 given along with proton craniospinal irradiation, a kind of radiation aimed at the brain and spine.
Where it stands. This trial has not reported results. The team is looking at whether this drug and radiation combination is safe. They are also looking at how well it works against the cancer. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: Nothing is proven here yet. Someone with melanoma or lung cancer that has spread this way might ask their care team about this study.
What it doesn't mean: This does not mean SX-682 with proton radiation is a proven treatment. A trial is a test. Joining one is not a promise that it will help you. This is not a cure.
Source: ClinicalTrials.gov, September 11, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.