Testing several study drugs for a brain tumor called glioblastoma
Original title: INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage trial, so the drugs are still being tested in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing several drugs to see if they may help treat glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary.
Who this trial is for. This trial is for people with glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary, a kind of brain tumor. It tests several drugs that are still being studied: abemaciclib, temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, neratinib, CC115, and QBS10072S.
Where it stands. This trial has not reported results. It is looking at whether these drugs may work as a treatment for glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. That answer is not in yet.
What this means, and what it doesn't
What it could mean: If you have glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary, you could ask your care team about this trial. They can help you learn if it might fit you. Note that some of the drug groups in this study are not taking new people.
What it doesn't mean: This does not mean these drugs work. A trial is a test, not a proven treatment. Joining a trial does not promise that it will help you. It is not a promise of a cure.
Source: ClinicalTrials.gov, August 19, 2026 · Read the original
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