Testing repeat radiation for glioblastoma that has come back
Original title: Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing how to safely give radiation again when a glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary returns after earlier radiation.
Who this trial is for. This trial is for adults aged 18 and older with grade 4 glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that came back after their first radiation treatment. It is testing radiation given to the tumor again, using different lengths of treatment, to look for a schedule that is safe.
Where it stands. The trial has not reported results. It is looking for a safe radiation schedule. People in the study have exams, blood tests, and scans, and they answer questions about their physical and mental health during treatment and at follow-up visits. The answer is not in yet.
What this means, and what it doesn't
What it could mean: There is no standard treatment for glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that returns after radiation. This study is one effort to find a safe way to use radiation a second time. Someone who fits this picture could ask their care team about it.
What it doesn't mean: This does not mean a new treatment has been proven. A trial is a test, not care your own doctor can give you. Joining one is not a guarantee that it will help. It is not a promise of a cure.
Source: ClinicalTrials.gov, July 14, 2026 · Read the original
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