Testing pembrolizumab with chemo for newly found brain and spine lymphoma
Original title: Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, mostly to check safety.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests adding a drug called pembrolizumab to chemo for lymphoma that starts in the brain or spine.
Who this trial is for. This trial is for people newly found to have primary central nervous system lymphoma. It tests pembrolizumab, a type of antibody drug, given with the chemo drugs methotrexate, temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, and rituximab.
Where it stands. The trial has not reported results. The team is checking if this drug mix helps the lymphoma. They are also watching how bad the side effects are. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: For now, this is a study, not care your own doctor can give you. Someone who fits the picture above could ask their care team about it. The care team can say if it makes sense to look into.
What it doesn't mean: This does not mean the drug mix works. A trial is a test, not a proven treatment. Joining a trial is not a promise that you will be helped. Some people get no benefit. This is not a cure, and it is not a promise of one.
Source: ClinicalTrials.gov, October 23, 2026 · Read the original
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