Testing olutasidenib with temozolomide for young people with IDH1-mutant high-grade glioma
Original title: Study of Olutasidenib and Temozolomide in HGG
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle-stage study, so the drug has been tried in people but is still being tested.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests whether adding a drug called olutasidenib to temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary helps young people with a certain kind of brain tumor live longer.
Who this trial is for. This trial is for children and young adults who were just diagnosed with a high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary. The tumor must have a change in a gene called IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary. The study tests the drug olutasidenib together with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, a chemotherapy drug.
Where it stands. There are no results yet. The study is measuring how well olutasidenib works, and whether the two drugs together help patients live longer. That answer is not in yet. The trial has not reported results.
What this means, and what it doesn't
What it could mean: For now, this is a question being asked, not an answer. If you or your child has a newly diagnosed high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary with an IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary change, you could ask your care team about this study. They can tell you if it makes sense for your situation.
What it doesn't mean: This does not mean the drug combination works. A trial is a test, not a proven treatment. Joining a trial is not a promise that it will help you. It is not a promise of a cure. Only the trial team can decide who can take part.
Source: ClinicalTrials.gov, September 1, 2026 · Read the original
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