Testing NST-628 in adults with grade 4 glioma that came back
Original title: A Phase 0/1 Study of NST-628 in Recurrent Grade 4 Glioma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, done to check safety and how the drug behaves.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a drug called NST-628 in adults whose grade 4 glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary has returned.
Who this trial is for. This trial is for adults with recurrent grade 4 glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary who are set to have surgery to remove the tumor. Their tumors must show high levels of a marker called pERK. Everyone in the trial gets NST-628. The team wants to see how the drug moves through the body, what it does to the tumor, how safe it is, and whether it acts against the tumor.
Where it stands. There are no results yet. The trial has not reported any findings. It is set up to measure how the body handles the drug, what the drug does in the body, safety, side effects, and any effect on the tumor. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: If you have grade 4 glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary that came back and surgery is being planned, this may be worth asking about. Your care team can tell you if a trial like this fits your situation. They can also explain what taking part would involve.
What it doesn't mean: This does not mean NST-628 works. A trial is a test, not a proven treatment. Joining a trial is not a promise that you will be helped. It is not a promise of a cure. No one can say yet whether this drug helps people with this tumor.
Source: ClinicalTrials.gov, August 25, 2026 · Read the original
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