Testing nivolumab, with or without relatlimab, for newly diagnosed glioblastoma
Original title: Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage study that is still checking safety and how the drugs act in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether the immune drug nivolumab, given alone or with relatlimab, is safe and workable for people with a newly diagnosed glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary.
Who this trial is for. This trial is for people with newly diagnosed glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary of the IDH wildtype kind. It tests nivolumab, given with or without a second drug called relatlimab, before and after surgery. People are placed into treatment groups by chance, and the study runs at more than one center.
Where it stands. This trial has not reported results. It is looking at whether this approach can be done, how safe it is, how well people handle it, and what the drugs do inside the body. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: For someone with a newly diagnosed glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary, this is one place where a new drug pairing is being studied. If it sounds like a fit, it is fair to ask your care team about it. They can tell you whether it makes sense for your situation.
What it doesn't mean: This does not mean the treatment works. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that it will help you. It is not a promise of a cure. And joining is not something we can promise. The trial team decides who can take part.
Source: ClinicalTrials.gov, July 31, 2026 · Read the original
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