Testing new radiation doses with temozolomide chemotherapy for IDH wildtype glioma
Original title: Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage study, so people are being treated but the answers are still being collected.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a different way of giving radiation, along with a chemotherapy pill, for a type of brain tumor called IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary wildtype glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary.
Who this trial is for. This trial is for people with an IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary wildtype glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary that was historically called grade II or grade III. Some hospitals now call these tumors IDH wildtype molecular glioblastomas. The study tests new radiation doses and radiation areas, given with the chemotherapy drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
Where it stands. This trial has not reported results. It is comparing the new radiation doses and areas to the treatment used before. It is also looking at whether adding temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary to radiation helps control the tumor. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: If you have this kind of glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary, this is one study looking at how best to give radiation and chemotherapy. You can ask your care team if a trial like this fits your situation. They can explain what joining would involve for you.
What it doesn't mean: This does not mean the treatment is proven. A trial is a test, not care your own doctor can give you yet. Being in a trial is not a guarantee that you will do better. It is not a promise of a cure.
Source: ClinicalTrials.gov, July 16, 2026 · Read the original
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