Testing morning versus evening timing for temozolomide in glioblastoma
Original title: The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a small first study in people, and it is mainly checking whether the plan can be followed.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether the time of day you take your temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary pill can be set, and what that is like for people with glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary.
Who this trial is for. This trial is for adults with glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary who are taking temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, a chemotherapy pill often given after brain surgery and radiation. Participants are randomly placed in a morning group or an evening group, take their pill at that time, write it down in a pill diary, and wear a wrist device during their first cycle.
Where it stands. This trial has not reported results. Its main question is whether people with glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary can stick to taking temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary at a set time of day. It is also looking at how many people join, safety, quality of life, the body's timing of the drug, and changes in people's condition over time. The answers are not in yet.
What this means, and what it doesn't
What it could mean: Right now this does not change how temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary is taken. The study is meant to help researchers plan a larger trial later. If you have glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary and are taking temozolomide, you could ask your care team whether a trial like this is worth looking into for you.
What it doesn't mean: This does not mean that taking the pill in the morning or the evening is better. A trial is a test, not a proven treatment. Joining a trial is not a guarantee that you will be helped. This is not a promise of a cure.
Source: ClinicalTrials.gov, July 16, 2026 · Read the original
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