Testing metformin for thinking and brain growth in children after brain tumor treatment
Original title: Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large late stage study, but it is still a test.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests a drug called metformin in young people who finished brain tumor treatment.
Who this trial is for. This trial is for children and teens ages 7 to 21 who have finished treatment for a brain tumor. They take metformin by mouth for 16 weeks, or a placebo. A placebo is a pill with no medicine in it.
Where it stands. The trial has not reported results. It is measuring thinking skills and brain growth. It compares metformin to the placebo over 16 weeks. The answer is not in yet.
What this means, and what it doesn't
What it could mean: Right now this is a study, not care your doctor can give you. If your child fits, you can ask their care team about it. The care team can explain what taking part would involve.
What it doesn't mean: This does not mean metformin helps thinking or brain growth. A trial is a test, not a proven treatment. Being in one is not a guarantee of benefit. It is not a promise of a cure.
Source: ClinicalTrials.gov, September 24, 2026 · Read the original
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