Testing metformin for PFA ependymoma that has come back or is growing
Original title: Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage trial, so the drug is still being tested in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing a drug called metformin in children and young adults whose PFA ependymoma has come back or is growing.
Who this trial is for. This trial is for children and young adults with Posterior Fossa Group A (PFA) ependymoma that has come back or is getting worse. It is testing metformin to see how the drug acts in the body and whether it helps.
Where it stands. This trial has not reported results. It is looking at what metformin does in the body and whether it works against this tumor. The answer is not in yet.
What this means, and what it doesn't
What it could mean: For now, this is a study, not care your own doctor can give you. If this sounds like your situation, you can ask your care team about it. They can tell you if it makes sense to look into.
What it doesn't mean: This does not mean metformin works for this tumor. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that you will be helped. It is not a promise of a cure.
Source: ClinicalTrials.gov, July 17, 2026 · Read the original
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