Testing levetiracetam added to standard treatment for hypoxic IDH-wildtype glioblastoma
Original title: Levetiracetam Extended-Release Plus Stupp Protocol for Hypoxic IDH-Wildtype Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage trial, so it is still being tested and is not care your own doctor can give you.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study asks if adding a drug called levetiracetam: A medicine that helps stop seizures. Many people with a brain tumor take it. In some people it also brings a short temper, anger or low mood. Tell your team if you notice that. See the glossary to the usual glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary treatment helps people do better.
Who this trial is for. This trial is for people with newly diagnosed hypoxic IDH-wildtype glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. That means a lab test showed the IDH-wildtype type, and the tumor has low oxygen. Some people get the usual care, which is surgery to remove as much tumor as is safe, then radiation with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. Others get that same care plus levetiracetam: A medicine that helps stop seizures. Many people with a brain tumor take it. In some people it also brings a short temper, anger or low mood. Tell your team if you notice that. See the glossary extended-release. The trial runs at more than one hospital.
Where it stands. This trial has not reported results. It is measuring how long people go before the tumor grows, and how long people live. It is also tracking side effects and quality of life. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: For now this does not change treatment. The usual care is still the usual care. If you were recently diagnosed and this sounds like your situation, you can ask your care team about it. They can tell you if it makes sense to look into.
What it doesn't mean: This does not mean levetiracetam: A medicine that helps stop seizures. Many people with a brain tumor take it. In some people it also brings a short temper, anger or low mood. Tell your team if you notice that. See the glossary is a proven treatment for glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. A trial is a test. Nobody knows yet if the added drug helps, and it may not. Joining a trial is not a guarantee that you will do better. This is not a cure, and it is not a promise of one.
Source: ClinicalTrials.gov, August 11, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.