Testing laser heat treatment plus lomustine for glioblastoma that came back
Original title: Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test, the first step in checking whether these two treatments can be used together.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether heating a tumor with a laser, then giving a chemo pill, is safe enough to use together.
Who this trial is for. This trial is for adults whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back. It tests laser ablation: Using heat from a laser to destroy tumor tissue. The laser goes in through a small hole in the skull, not a large opening. It suits some tumors and not others. Not every hospital offers it. See the glossary, called LITT, followed by the chemo drug lomustine: A chemotherapy taken as a capsule, only occasionally rather than every day. It lowers blood counts weeks after a dose, which is why the doses are spaced out. See the glossary.
Where it stands. The trial has not reported results. The team is checking how safe the two treatments are together, and whether patients can finish both on the planned schedule. They also plan to look at how long people live for up to 2 years after the first dose of lomustine: A chemotherapy taken as a capsule, only occasionally rather than every day. It lowers blood counts weeks after a dose, which is why the doses are spaced out. See the glossary. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: If your glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back, this is one of the options being studied right now. Someone who thinks they might fit could ask their care team about it. Your team can tell you if it makes sense for your situation.
What it doesn't mean: This does not mean the combination works. A trial is a test, not a proven treatment. Joining a study is not a guarantee that it will help you, and it is not a promise of a cure. The safety of putting these two treatments together is still being worked out.
Source: ClinicalTrials.gov, September 28, 2026 · Read the original
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