Testing lab-changed immune cells in people whose glioblastoma has come back
Original title: GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, so it is not care your own doctor can give you.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests immune cells that are changed in a lab so they can find and kill brain tumor cells.
Who this trial is for. This trial is for people with glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that has come back and whose tumor has a protein called GPC-3. The study team changes the person's own T cells, a kind of blood cell that fights disease, so the cells can spot that protein and attack the tumor.
Where it stands. This trial has not reported results. It is testing these changed T cells, called GO-CART T cells, in people for the first time. The study team is looking at how safe they are and how they act in the body. The answer is not in yet.
What this means, and what it doesn't
What it could mean: If your glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back, you could ask your care team about this study. They know your case and can say whether it is worth looking into. They can also explain what taking part would involve.
What it doesn't mean: This does not mean these cells are a treatment you can get. A trial is a test, not proven care. Being in a trial is not a promise that it will help you. These cells are not approved by the Food and Drug Administration, and this is not a cure.
Source: ClinicalTrials.gov, September 30, 2026 · Read the original
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