Testing high-dose methotrexate for breast cancer that has spread to the brain lining
Original title: Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle-stage trial, so the drug is still being tested in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests high-dose methotrexate for breast cancer that spread to the brain lining.
Who this trial is for. This trial is for people whose breast cancer has spread to the lining of the brain and spinal cord. It tests high-dose methotrexate, given through a vein, in triple negative, HER2-positive, and hormone refractory breast cancer.
Where it stands. This trial has not reported results. It is watching what happens when people get this high dose of methotrexate. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: If this sounds like your situation, you can ask your care team about it. They can say whether a trial like this fits your care plan. The trial team decides who can take part.
What it doesn't mean: A trial is a test, not a proven treatment. Taking part does not mean a person will get better. This is not a promise of a cure.
Source: ClinicalTrials.gov, October 5, 2026 · Read the original
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