Testing GD2 CAR T cells for brain tumors that carry the GD2 protein
Original title: C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in people, done to find a safe dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing immune cells that are changed in a lab to find and attack brain tumor cells that carry a protein called GD2.
Who this trial is for. This trial is for people with a brain tumor that has GD2 on it. That includes diffuse midline glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary, diffuse intrinsic pontine glioma, medulloblastoma, and other rare high-grade gliomas, with a separate group for progressive diffuse intrinsic pontine glioma. It is testing T cells, a kind of white blood cell, that are changed in a lab so they can recognize GD2. An added gene called C7R is meant to help those cells live longer. Chemotherapy is given first to help the T cells last. The cells are given into a vein in the first cycle, then into the fluid around the brain through an Ommaya reservoir or a programmable VP shunt.
Where it stands. This trial has not reported results. The team is looking for the largest dose of these T cells that is safe to give this way. They are also checking how long the cells can be found in the blood and in the fluid around the brain, and what effect the cells have on the tumor. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: This is one of the ways researchers are trying to use a person's own immune cells against brain tumors. These cells are not approved by the FDA. If your tumor type is listed here, you could ask your care team whether a study like this is worth looking into for you.
What it doesn't mean: This does not mean the treatment works. A trial is a test, not proven care. Joining a trial is not a guarantee that it will help you, and side effects are possible. It is not a promise of a cure. Whether anyone can take part is decided by the trial team.
Source: ClinicalTrials.gov, August 3, 2026 · Read the original
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