Testing entacapone added to bevacizumab for glioblastoma that has come back
Original title: Entacapone Plus Bevacizumab for Glioblastoma at First Recurrence
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people that first checks safety before a larger comparison.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests whether adding a pill called entacapone to the drug bevacizumab: A drug that acts on the blood vessels a tumor builds. In brain tumors it is used mainly to control symptoms from swelling, and to reduce how much steroid someone needs. See the glossary is safe and helps adults whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back for the first time.
Who this trial is for. This trial is for adults whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back once after the usual first treatment. They must not have had bevacizumab: A drug that acts on the blood vessels a tumor builds. In brain tumors it is used mainly to control symptoms from swelling, and to reduce how much steroid someone needs. See the glossary before, and more surgery must not be a good choice for them, or they chose not to have it.
Where it stands. The trial has not reported results. First, a small group will get both drugs so the team can check safety. If it looks safe enough, a larger group will get bevacizumab: A drug that acts on the blood vessels a tumor builds. In brain tumors it is used mainly to control symptoms from swelling, and to reduce how much steroid someone needs. See the glossary plus either entacapone or a dummy pill. The team will then see how long the cancer stays from growing.
What this means, and what it doesn't
What it could mean: This trial asks whether an added pill can help bevacizumab: A drug that acts on the blood vessels a tumor builds. In brain tumors it is used mainly to control symptoms from swelling, and to reduce how much steroid someone needs. See the glossary work better for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that has come back. Someone who fits might ask their care team if this trial could be right for them. The trial team decides who can join.
What it doesn't mean: A trial is a test, not a proven treatment. Being in a trial does not mean it will help you. This is not a promise of a cure. Some people in the second stage will get a dummy pill instead of entacapone.
Source: ClinicalTrials.gov, September 21, 2026 · Read the original
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