Testing Endostar for brain swelling after radiation in lung cancer that spread to the brain
Original title: Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases.
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle-stage test in people, so we still do not know if it helps.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests a drug called Endostar for brain swelling after a focused radiation treatment.
Who this trial is for. This trial is for people with non-small cell lung cancer that spread to the brain. They have had focused radiation called stereotactic radiosurgery: Radiation aimed at a small target, in one visit or a few. There is no cutting, despite the name. See the glossary. One group gets Endostar early to try to prevent brain injury. Another group gets it later, after brain injury shows up.
Where it stands. The trial has not reported results. The main thing being measured is whether swelling around the tumor gets better. It also looks at nerve function, quality of life, and how long people live. It checks how easy the 72-hour continuous drip is to take. The answers are not in yet.
What this means, and what it doesn't
What it could mean: If this drug helps, it could give doctors a way to ease brain swelling after this radiation. Nobody knows yet if it does. Someone who fits this picture could ask their care team about the trial.
What it doesn't mean: This does not mean the drug works. A trial is a test, not a proven treatment. Being in one is not a promise of any benefit. It is not a cure.
Source: ClinicalTrials.gov, September 25, 2026 · Read the original
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