Testing disulfiram before brain surgery in people with high grade glioma
Original title: Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High Grade Glioma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early study in people, done mainly to check safety.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is looking at whether an older drug, given before surgery, can make a brain tumor easier for the immune system to fight and cut down on brain swelling.
Who this trial is for. This trial is for people with glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary whose tumor can be removed with surgery. It tests disulfiram, a drug already used for other conditions, taken before that surgery.
Where it stands. There are no results yet. The study is measuring whether disulfiram makes the area around the tumor less able to block the immune system, and whether it reduces brain swelling. The trial has not reported any findings, so we do not know if it works.
What this means, and what it doesn't
What it could mean: Right now this is a question being asked, not an answer. If your situation sounds like the one described here, you can bring this study up with your care team and ask if it is worth looking into for you.
What it doesn't mean: This does not mean disulfiram treats brain tumors. A trial is a test, not a proven treatment. Joining a study is not a guarantee that it will help you, and it is not a promise of a cure. The trial team decides who can take part.
Source: ClinicalTrials.gov, July 22, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.