Testing chemo seeds placed in the brain during glioblastoma surgery
Original title: Irinotecan-ChemoSeed in Surgically Resectable Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a mid-stage trial, so the treatment is still being tested and is not standard care.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests small drug seeds placed in the space left after glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary surgery.
Who this trial is for. This trial is for people with glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary who can have as much of the tumor removed as is safe. Part 1 includes 12 people whose glioblastoma has come back. Part 2 includes 135 people with newly found glioblastoma. It tests seeds that hold the drug irinotecan, placed in the edge of the space left after surgery, along with standard care.
Where it stands. The trial has not reported results. Part 1 is looking at safety and at how much of the drug can be used. Part 2 compares the seeds plus standard care against standard care alone. Standard care here means surgery, radiation, and the drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. The answers are not in yet.
What this means, and what it doesn't
What it could mean: If you or someone you care for has glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary, this is one more thing being tried. Someone who fits the picture above could ask their care team about it. The care team can say whether it makes sense and whether a spot is possible.
What it doesn't mean: This does not mean the seeds work. A trial is a test, not proven treatment. Joining one is not a guarantee that it will help you. It is not a promise of a cure. We do not know yet if this is better than standard care alone.
Source: ClinicalTrials.gov, September 3, 2026 · Read the original
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