Testing B7-H3 CAR T cell therapy in children and young adults with brain tumors that came back
Original title: B7-H3.CD28Z.CART in CNS Neoplasms
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, looking first at safety and dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing a cell therapy for young people whose brain tumor came back or kept growing.
Who this trial is for. This trial is for children and young adults with a brain tumor that came back or kept growing. It tests a cell therapy called B7-H3 CAR T cells, given at different dose levels, along with two chemotherapy drugs, fludarabine and cyclophosphamide.
Where it stands. The trial is looking at how safe this cell therapy is and how well it works. It has not reported results. There is no answer yet about whether it helps.
What this means, and what it doesn't
What it could mean: B7-H3 is a protein found in large amounts on many tumor cells. That is why it was picked as a target here. A family whose situation fits could ask their care team about this study.
What it doesn't mean: This does not mean the therapy works. A trial is a test, not a proven treatment. Joining one is not a promise of any benefit, and it is not a cure. The trial team decides who can take part.
Source: ClinicalTrials.gov, September 3, 2026 · Read the original
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