Testing B7-H3 CAR T Cell Therapy Given Into the Brain for Adults With Glioblastoma That Has Come Back
Original title: B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a first test in people, mainly to check safety.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests whether a type of immune cell treatment can be made and safely given into the brain for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that has come back.
Who this trial is for. This trial is for adults whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back and whose tumor is the IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary wild-type kind. It tests B7-H3 CAR T cells, a type of immune cell treatment, given right into the brain and spinal fluid area.
Where it stands. The team is checking two things. Can the cells be made for each person, and is it safe to give them this way? Each small group of people gets a higher dose than the group before. The trial has not reported results.
What this means, and what it doesn't
What it could mean: This is an early step to learn if this treatment is safe to test further. If you or someone you care for has glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that came back, you could ask your care team if this trial might fit. The trial team decides who can join.
What it doesn't mean: This trial is a test. It is not a proven treatment. Being in it does not mean it will help you. It is not a cure, and it does not promise one.
Source: ClinicalTrials.gov, September 15, 2026 · Read the original
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