Testing an immune drug plus focused radiation before surgery for glioblastoma that has come back
Original title: Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, mostly to check safety.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests whether an immune drug and radiation can be safely given before surgery for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that returned.
Who this trial is for. This trial is for people whose glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary has come back. It tests a drug called pembrolizumab, which works with the immune system, along with focused radiation, both given before surgery to remove the tumor.
Where it stands. The trial has not reported results yet. It is looking at side effects and whether surgery can still happen on time. It is also tracking how long people live, how long the tumor stays in check, and how immune cells respond.
What this means, and what it doesn't
What it could mean: This trial is checking if this plan is safe and doable before surgery. If you or someone you care for has glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary that came back, you could ask your care team if this trial might fit. The trial team decides who can join.
What it doesn't mean: A trial is a test, not a proven treatment. Joining one does not mean it will help you. This is not a cure, and no one knows yet if this plan works.
Source: ClinicalTrials.gov, September 21, 2026 · Read the original
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